In a study published in Molecular Therapy Advances a team of researchers led by Professor Haruhisa Inoue (Center for iPS Cell Research and Application, Kyoto University) and Professor Yuishin Izumi ...

Our cells accumulate DNA mistakes as we age, eating less slowed that process in mice Every cell carries a molecular record of time. As DNA is copied, repaired and exposed to damage, mutations ...

In simple terms: a mutation is a stable change in genetic sequence that can be copied when cells or viruses replicate. Most mutations have no detectable effect, some contribute to disease, and a small ...

Most lethal mutations in wild fruit flies are driven by newly transferred jumping genes, not small DNA errors, according to a new study from Duke University. The findings, published in PLOS Biology, ...

Autism spectrum disorder (ASD) is associated with more than 1,200 risk genes, raising a fundamental question: Do these ...

A new study has punctured a longstanding assumption about the source of the most common type of DNA mutation seen in the genome--one that contributes to many genetic diseases, including cancer. A ...

Avian influenza viruses typically require several mutations to adapt and spread among humans, but what happens when just one change can increase the risk of becoming a pandemic virus? A study led by ...

Moderate levels of mitochondrial DNA mutations may promote cancer more effectively than either low or high levels. And metabolic plasticity appears to be a key driver. After decades of fixating on ...

Mutation dynamics and fitness effects lie at the heart of evolutionary change. Every generation, genomes accrue spontaneous alterations ranging from single-nucleotide substitutions to larger ...

The findings, published Sept. 10 in Science, provide an explanation for at least some of the patients whose PCD has been a genetic mystery and could improve doctors’ ability to diagnose the disease.

A new platform for studying mitochondrial DNA mutations implicated in human disease could revolutionize research in health, disease and evolution, and accelerate efforts to develop treatments for ...

Researchers show mutant NRAS and wild-type HRAS cooperate in cancer signaling, pointing to mutation-guided combination ...